Rams vs. 49ers odds, spread, line: Monday Night Football

SportsLine simulated San Francisco 49ers vs. Los Angeles Rams on Monday Night Football 10,000 times and made its best bet

This will be a battle between two offensive masterminds in Kyle Shanahan and Sean McVay.

Both teams are 1-2 against the spread this season.

Anyone who has followed it is way up.

Now, the model has broken down Monday's 49ers vs. Rams matchup and just locked in its picks and MNF predictions.

 Rams vs. 49ers over/under: 42.5 point

Kickoff is scheduled for 8:15 p.m. from Levi's Stadium in Santa Clara, California.